tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate

Name	tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
Synonyms	N3-PEG3-tBu Azido-PEG3-COOtBu N3-PEG3-CH2CH2COOtBu N3-?PEG3-?t-?butyl ester tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester
CAS	252881-73-5

Molecular Formula	C13H25N3O5
Molar Mass	303.3547
Storage Condition	2~8℃,干燥,密封
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

biological activity	N3-PEG3-CH2CH2-Boc is a degradable (cleavable) ADC linker containing 3 unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). N3-PEG3-CH2CH2-Boc is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.
target	PEGs Alkyl/ether Cleavable
in vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-09 21:54:55

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